Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: HLLFPLTLVR SFWSDMMDSA QSFITSSWTF YLQADDGKIV IFQSKPEIQY APHLEQEPTN LRESSLSKMS SDLQMRNSQA HRNFLEDGES DGFLRCLSLN SGW
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dendritic cell factor 1; Liver membrane-bound protein; RP4-758J24.2; Transmembrane protein 59
Gene Aliases: C1orf8; DCF1; HSPC001; PRO195; TMEM59; UNQ169; UNQ169/PRO195
UniProt ID: (Human) Q9BXS4
Entrez Gene ID: (Human) 9528
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