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A suggested positive control is human kidney tissue lysate.
PA5-21065 can be used with blocking peptide PEP-1179.
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
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Protein Aliases: dendritic cell factor 1; Liver membrane-bound protein; RP4-758J24.2; Transmembrane protein 59
Gene Aliases: C1orf8; DCF1; HSPC001; PRO195; TMEM59; UNQ169; UNQ169/PRO195
UniProt ID: (Human) Q9BXS4
Entrez Gene ID: (Human) 9528