Immunogen sequence: YSPPPYSEYPP FSHRYQRFTN SAGPPPPGFK SEFTGPQNTG HGATSGFGSA FT
Highest antigen sequence identity to the following orthologs - mouse 75%, rat 70%.
Saraf encodes a protein that is a negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the de-oligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HBV X-transactivated gene 3 protein; HBV XAg-transactivated protein 3; Protein FOAP-7; SARAF; SARAF long isoform; SARAF short isoform; SOCE-associated regulatory factor; Store-operated calcium entry-associated regulatory factor; testicular secretory protein Li 59; Transmembrane protein 66
Gene Aliases: FOAP-7; HSPC035; NPD003; PSEC0019; SARAF; TMEM66; UNQ1967/PRO4499; XTP3
UniProt ID: (Human) Q96BY9
Entrez Gene ID: (Human) 51669