PA5-30927 targets TMPRSS11D in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30927 immunogen is recombinant fragment corresponding to a region within amino acids 152 and 388 of Human TMPRSS11D.
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This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
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Protein Aliases: airway trypsin like protease; Airway trypsin-like protease; HAT; Transmembrane protease serine 11D; Transmembrane protease serine 11D catalytic chain; Transmembrane protease serine 11D non-catalytic chain
Gene Aliases: HAT; TMPRSS11D
UniProt ID: (Human) O60235
Entrez Gene ID: (Human) 9407
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule