Peptide sequence: RSSFQLLNVE YNSQLNSPAT QEYRTLSGRI ESLITKTFKE SNLRNQFIRA
Sequence homology: Guinea Pig: 79%; Horse: 79%; Human: 100%; Rabbit: 79%
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: airway trypsin like protease; Airway trypsin-like protease; HAT; MGC150587; MGC150588; serine 11D; Transmembrane protease; Transmembrane protease serine 11D; Transmembrane protease serine 11D catalytic chain; Transmembrane protease serine 11D non-catalytic chain; transmembrane protease, serine 11D-like
Gene Aliases: HAT; TMPRSS11D
UniProt ID: (Human) O60235
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule