This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008].
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Protein Aliases: Enterokinase; enterokinase catalytic subunit; Enteropeptidase; Enteropeptidase catalytic light chain; Enteropeptidase non-catalytic heavy chain; ENTK; protease, serine, 7 (enterokinase); PRSS7; Serine protease 7; TMPRSS15; Transmembrane protease serine 15
Gene Aliases: ENTK; PRSS7; TMPRSS15
UniProt ID: (Human) P98073
Entrez Gene ID: (Human) 5651
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule