This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CAPH2; Channel-activating protease 2; Membrane-type serine protease 2; MT-SP2; TMPRSS3; Transmembrane protease serine 4; transmembrane protease, serine 4; transmembrane serine protease 3; type II membrane serine protease
Gene Aliases: CAPH2; MT-SP2; TMPRSS3; TMPRSS4; UNQ776/PRO1570
UniProt ID: (Human) Q9NRS4
Entrez Gene ID: (Human) 56649
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule