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Invitrogen
TMPRSS6 Polyclonal Antibody
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Product Details
PA5-43989
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human TMPRSS6 (aa 71-120).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK
Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
Target Information
TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; Transmembrane protease serine 6; type II transmembrane serine protease 6
Gene Aliases: IRIDA; TMPRSS6; UNQ354/PRO618
UniProt ID: (Human) Q8IU80
Entrez Gene ID: (Human) 164656
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
proteolysis
cellular iron ion homeostasis
extracellular matrix organization
negative regulation of BMP signaling pathway
membrane protein proteolysis
intracellular signal transduction
fibrinolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
self proteolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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