|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG1, kappa|
|Storage buffer||PBS, pH 7.2|
|Tested Applications||Dilution *|
|Functional Assay (FN)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Macrophage interactions with neutrophils regulate Leishmania major infection.
AMC3812 was used in blocking assay to determine role of macrophage interactions with inflammatory neutrophils for the control of L. major infection.
|Ribeiro-Gomes FL,Otero AC,Gomes NA,Moniz-De-Souza MC,Cysne-Finkelstein L,Arnholdt AC,Calich VL,Coutinho SG,Lopes MF,DosReis GA||Journal of immunology (Baltimore, Md. : 1950) (172:4454)||2004|