Keep as concentrated solution.
Positive Control: 3xFlag-human TNFAIP3-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A20 antibody; A20p37; A20p50; alpha-induced protein 3 antibody; MGC104522 antibody; MGC138687 antibody; MGC138688 antibody; OTU domain-containing protein 7C; OTU domain-containing protein 7C antibody; OTUD7C antibody; Putative DNA-binding protein A20; putative DNA-binding protein A20 antibody; TNF alpha-induced protein 3; TNF alpha-induced protein 3 antibody; TNFA1P2 antibody; TNFAIP3 (A20) antibody; TNFAIP3 antibody; tumor necrosis factor; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor alpha-induced protein 3 antibody; tumor necrosis factor inducible protein A20; tumor necrosis factor inducible protein A20 antibody; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20; zinc finger protein A20 antibody
Gene Aliases: A20; AISBL; OTUD7C; TNFA1P2; TNFAIP3
UniProt ID: (Human) P21580
Entrez Gene ID: (Human) 7128