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Invitrogen
TNFAIP6 Polyclonal Antibody
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FIGURE: 1 / 2
TNFAIP6 Antibody (PA5-75332) in IHC (P)
Immunohistochemistry analysis of TNFAIP6 in paraffin-embedded human breast carcinoma tissue (cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with TNFAIP6 polyclonal antibody (Product # PA5-75332) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-75332
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the N-terminal of Human TNFAIP6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNF alpha, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (I alpha I)). TSG-6 potentiates the inhibitory effect of l alpha l on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and l alpha l can modulate the protease network and thus inhibit inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hyaluronate-binding protein; TNF alpha-induced protein 6; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor induced protein 6; tumor necrosis factor, alpha induced protein 6; tumor necrosis factor, alpha-induced protein 6; Tumor necrosis factor-inducible gene 6 protein; tumor necrosis factor-stimulated gene-6 protein
Gene Aliases: TNFAIP6; Tnfip6; TSG-6; TSG6
UniProt ID: (Human) P98066, (Mouse) O08859
Entrez Gene ID: (Human) 7130, (Mouse) 21930
cell adhesion
positive regulation of cell migration
negative regulation of inflammatory response
ovarian cumulus expansion
inflammatory response
signal transduction
cell-cell signaling
hyaluronan metabolic process
negative regulation of BMP signaling pathway
negative regulation of osteoblast differentiation
negative regulation of osteoclast differentiation
negative regulation of neutrophil chemotaxis
positive regulation of receptor clustering
fibronectin fibril organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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