TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFkappa B. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.
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Protein Aliases: Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NDED; NF-kappa-B-inducible DED-containing protein; SCC S2; SCC-S2; TNF alpha-induced protein 8; TNF-induced protein; TNF-induced protein GG2-1; TNFalpha IP8; TNFalpha-IP 8; TNFalphaIP8; Tumor necrosis factor alpha-induced protein 8; tumor necrosis factor, alpha induced protein 8; tumor necrosis factor, alpha-induced protein 8
Gene Aliases: AA987150; E130304C20Rik; ENSMUSG00000073567; GG2-1; Gm10539; MDC-3.13; NDED; SCC-S2; SCCS2; Ssc-2; TNFAIP8