Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: A431, HeLa.
Predicted reactivity: Mouse (94%), Rat (93%), Xenopus laevis (84%), Pig (95%), Chicken (89%), Rhesus Monkey (98%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFkappa B. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NDED; NF-kappa-B-inducible DED-containing protein; SCC S2; SCC-S2; TNF alpha-induced protein 8; TNF-induced protein GG2-1; TNFalpha IP8; TNFalpha-IP 8; TNFalphaIP8; Tumor necrosis factor alpha-induced protein 8; tumor necrosis factor, alpha induced protein 8; tumor necrosis factor, alpha-induced protein 8
Gene Aliases: GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2; TNFAIP8
UniProt ID: (Human) O95379
Entrez Gene ID: (Human) 25816
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support