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Invitrogen
TNFR2 Recombinant Rabbit Monoclonal Antibody (R204)
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TNFR2 Antibody (MA5-29837) in Neu
Mouse TNFR2 Inhibition of Mouse TNFalpha-induced Cytotoxicity and Neutralization by TNFR2 Recombinant Rabbit Monoclonal Antibody (R204). Recombinant Mouse TNFRSF1B inhibits Recombinant Mouse TNFalpha induced cytotoxicity in the L-929 mouse fibroblast cell line. Inhibition of Recombinant Mouse TNFalpha (0.5 ng/mL) activity elicited by Recombinant Mouse TNFR2 (25 ng/mL) is neutralized by increasing concentrations of TNFR2 Recombinant Rabbit Monoclonal Antibody (R204) (Product # MA5-29837). The ND50is typically 16-50 ng/mL in the presence of ... View More
Product Details
MA5-29837
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R204
Immunogen
Recombinant Mouse TNFR2/TNFRSF1B/CD120b protein (Met1-Gly258)
Conjugate
Form
Liquid
Concentration
2.64 mg/mL
Purification
Protein A
Storage buffer
Histidine/arginine, pH 6, with 120mM NaCl, 0.02% Tween 80
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse TNFR2/TNFRSF1B/CD120b.
Target Information
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD120b; p75; p75 TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TNF receptor beta chain; TNF-R2; TNF-RII; TNFR; TNFR II; TNFR-II; Tumor necrosis factor receptor; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor type II
Gene Aliases: CD120b; p75; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr-2; Tnfr2; TNFR80; TNFRII; Tnfrsf1b
UniProt ID: (Mouse) P25119
Entrez Gene ID: (Mouse) 21938
inflammatory response
immune response
cell surface receptor signaling pathway
cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
programmed cell death
tumor necrosis factor-mediated signaling pathway
negative regulation of inflammatory response
RNA destabilization
positive regulation of membrane protein ectodomain proteolysis
cellular response to lipopolysaccharide
extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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