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Proteintech
TNFSF13B Polyclonal Antibody
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Product Details
11862-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TNFSF13B Fusion Protein Ag2440 (1-285 aa encoded by BC020674)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes all the forms of TNFSF13B such as soluble form (17 kDa), membrane form (32-35 kDa) and glycosylation form (45-52 kDa).
Immunogen sequence: MDDSTEREQ SRLTSCLKKR EEMKLKECVS ILPRKESPSV RSSKDGKLLA ATLLLALLSC CLTVVSFYQV AALQGDLASL RAELQGHHAE KLPAGAGAPK AGLEEAPAVT AGLKIFEPPA PGEGNSSQNS RNKRAVQGPE ETVTQDCLQL IADSETPTIQ KGSYTFVPWL LSFKRGSALE EKENKILVKE TGYFFIYGQV LYTDKTYAMG HLIQRKKVHV FGDELSLVTL FRCIQNMPET LPNNSCYSAG IAKLEEGDEL QLAIPRENAQ ISLDGDVTFF GALKLL (1-285 aa encoded by B C020674)
Target Information
BAFF is a membrane bound cytokine expressed by B cell lineage cells. The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells. BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival. Isoforms representing alternatively spliced, and glycosylated variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ApoL related ligand TALL-1; b cell-activating factor; B lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLyS; CD257; delta BAFF; Delta4 BAFF; Dendritic cell-derived TNF-like molecule; epididymis secretory sperm binding protein; TALL-1; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF ligand superfamily member; TNF- and APOL-related leukocyte expressed ligand 1; TNF-like cytokine; TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand 7A; Tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor superfamily member 13b; tumor necrosis factor-like protein ZTNF4
Gene Aliases: BAFF; BLYS; CD257; D8Ertd387e; DTL; RGD1561519; TALL-1; TALL1; THANK; TNFSF13B; TNFSF20; TNLG7A; UNQ401/PRO738; ZTNF4
UniProt ID: (Human) Q9Y275, (Mouse) Q9WU72
Entrez Gene ID: (Human) 10673, (Mouse) 24099, (Rat) 498666
B cell homeostasis
positive regulation of germinal center formation
immune response
positive regulation of B cell proliferation
T cell costimulation
B cell costimulation
positive regulation of T cell proliferation
immunoglobulin secretion
regulation of immune response
lymphocyte homeostasis
transitional one stage B cell differentiation
immune system process
germinal center formation
cell communication
signal transduction
signaling
B cell differentiation
tumor necrosis factor-mediated signaling pathway
T cell proliferation
B cell proliferation
skin development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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