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TNFSF4 Polyclonal Antibody

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TNFSF4 Polyclonal Antibody

Product Details

600-401-FL1

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-TNFSF4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid peptide near the C-terminus of human TNFSF4.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: atherosclerosis 1; CD134 ligand; CD252; Glycoprotein Gp34; OX 40 ligand/ gp 34; OX40 antigen ligand; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); tax-transcriptionally activated glycoprotein 1 ligand; TNFSF4; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor ligand 2B; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; unnamed protein product

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Gene Aliases: Ath-1; Ath1; CD134L; CD252; GP34; OX-40L; Ox40l; OX4OL; TNFSF4; TNLG2B; TXGP1; Txgp1l

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UniProt ID: (Human) P23510, (Rat) Q9Z2P3, (Mouse) P43488

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Entrez Gene ID: (Human) 7292, (Rat) 89814, (Mouse) 22164

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Function(s)
receptor binding cytokine activity tumor necrosis factor receptor binding protein binding tumor necrosis factor receptor superfamily binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of cytokine production defense response to nematode acute inflammatory response positive regulation of immunoglobulin production positive regulation of T cell cytokine production regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of immunoglobulin mediated immune response inflammatory response immune response cell communication signal transduction positive regulation of cell proliferation response to virus signaling negative regulation of interferon-gamma production negative regulation of interleukin-17 production positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production memory T cell activation T-helper 2 cell activation response to nitrogen dioxide positive regulation of T cell proliferation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of memory T cell differentiation negative regulation of regulatory T cell differentiation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of alpha-beta T cell proliferation regulation of inflammatory response positive regulation of inflammatory response positive regulation of B cell activation cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus positive regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of interleukin-4-dependent isotype switching to IgE isotypes cytokine production cholesterol metabolic process positive regulation of interleukin-2 production cellular response to nitrogen dioxide CD4-positive, alpha-beta T cell costimulation T cell proliferation positive regulation of activated T cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated negative regulation of cytokine secretion positive regulation of immunoglobulin secretion chemokine (C-C motif) ligand 11 production positive regulation of T cell costimulation positive regulation of memory T cell activation positive regulation of T-helper 2 cell activation blood vessel development positive regulation of immune effector process innate immune response negative regulation of T cell apoptotic process negative regulation of activation-induced cell death of T cells positive regulation of T cell migration negative regulation of extrinsic apoptotic signaling pathway
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