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Product Details
15459-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TNIP2 Fusion Protein Ag7731 (76-429 aa encoded by BC002740)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EQLRRQEGG AAEAQMRQEI ERLTERLEEK EREMQQLLSQ PQHEREKEVV LLRRSMAEGE RARAASDVLC RSLANETHQL RRTLTATAHM CQHLAKCLDE RQHAQRNVGE RSPDQSEHTD GHTSVQSVIE KLQEENRLLK QKVTHVEDLN AKWQRYNASR DEYVRGLHAQ LRGLQIPHEP ELMRKEISRL NRQLEEKIND CAEVKQELAA SRTARDAALE RVQMLEQQIL AYKDDFMSER ADRERAQSRI QELEEKVASL LHQVSWRQDS REPDAGRIHA GSKTAKYLAA DALELMVPGG WRPGTGSQQP EPPAEGGHPG AVQRGQGDLQ CPHCLQCFSD EQGEELLRHV AECCQ (76-429 aa encoded by B C002740)
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A20 binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; ABIN-2; Fetal liver LKB1-interacting protein; TNFAIP3-interacting protein 2; TNIP2
Gene Aliases: 1810020H16Rik; ABIN-2; ABIN2; AI428870; FLIP1; KLIP; TNIP2
UniProt ID: (Human) Q8NFZ5, (Mouse) Q99JG7
Entrez Gene ID: (Human) 79155, (Mouse) 231130, (Rat) 305451
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
inflammatory response
I-kappaB kinase/NF-kappaB signaling
CD40 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 9 signaling pathway
positive regulation of macrophage activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
protein stabilization
positive regulation of B cell activation
interleukin-1-mediated signaling pathway
cellular response to lipopolysaccharide
negative regulation of endothelial cell apoptotic process
stress-activated MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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