Suggested positive control: antigen standard for TNIP2 (transient overexpression lysate), mouse heart or lung tissue, mouse heart protein.
ABIN-2, TNFAIP3 interacting protein 2, binds to the COOH-terminal zinc finger domain of A20. NF-kB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2. The latter also inhibits NF-kB activation induced by overexpression of receptor-interacting protein or TNF receptor-associated factor 2. A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB)Activation (ABIN-2) binds to A-20. ABIN-2 interferes with NF-kB activation upstream of the IKK complex and might contribute to NF-kB inhibitory function of A-20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A20 binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; ABIN-2; Fetal liver LKB1-interacting protein; FLIP1; TNFAIP3-interacting protein 2; TNIP2
Gene Aliases: 1810020H16Rik; ABIN-2; ABIN2; AI428870; FLIP1; KLIP; TNIP2