Immunogen sequence: EDLNAKWQRY NASRDEYVRG LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQM
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 82%.
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; ABIN-2; ABIN2; Fetal liver LKB1-interacting protein; FLIP1; KLIP; TNFAIP3-interacting protein 2; TNIP2
Gene Aliases: ABIN2; FLIP1; KLIP; TNIP2
UniProt ID: (Human) Q8NFZ5
Entrez Gene ID: (Human) 79155