Immunogen sequence: QDIKPRFHKSR TVTLPHEAER PDGSEDAEDD DD
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 97%.
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: importin 3; IPO3; karyopherin beta 2b; karyopherin beta 2b); karyopherin beta 2b, transportin; Karyopherin beta-2b; KPNB2B; transportin; transportin 2 (importin 3; transportin 2 (importin 3, karyopherin beta 2b); Transportin-2; TRN2
Gene Aliases: IPO3; KPNB2B; TNPO2; TRN2
UniProt ID: (Human) O14787
Entrez Gene ID: (Human) 30000