TOB2 is a 344 amino acid rich novel member of the Tob/BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG/Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues.
Protein Aliases: Protein Tob2; Protein Tob4; Transducer of erbB-2 2
Gene Aliases: 2900090N22Rik; 4930545K18Rik; APRO5; AV071822; KIAA1663; mKIAA1663; TOB2; TOB4; TOBL; TROB2