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Abnova
TOLLIP Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 3
TOLLIP Antibody (H00054472-D01P) in WB
Western Blot analysis of TOLLIP expression in transfected 293T cell line (H00054472-T02) by TOLLIP MaxPab polyclonal antibody.
Lane 1: TOLLIP transfected lysate(30.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: TOLLIP transfected lysate(30.30 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00054472-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TOLLIP (NP_061882.2, 1 a.a. approximately 274 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG TVGRLNITVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIHCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLRQGKVEDK WYSLSGRQGD DKEGMINLVM SYALLPAAMV MPPQPVVLMP TVYQQGVGYV PITGMPAVCS PGMVPVALPP AAVNAQPRCS EEDLKAIQDM FPNMDQEVIR SVLEAQRGNK DAAINSLLQM GEEP
Target Information
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adapter protein; FLJ33531; Toll-interacting protein; TOLLIP; unnamed protein product
Gene Aliases: 4930403G24Rik; 4931428G15Rik; IL-1RAcPIP; TOLLIP
UniProt ID: (Human) Q9H0E2, (Mouse) Q9QZ06
Entrez Gene ID: (Human) 54472, (Mouse) 54473
immune system process
ubiquitin-dependent protein catabolic process
autophagy
inflammatory response
signal transduction
phosphorylation
epithelial cell differentiation
positive regulation of protein sumoylation
protein localization to endosome
innate immune response
leukocyte activation
interleukin-1-mediated signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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