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TOP1MT Antibody (PA5-110509) in IHC (P)
Immunohistochemistry analysis of TOP1MT in paraffin-embedded human colon. Samples were incubated with TOP1MT Polyclonal antibody (Product # PA5-110509) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-110509
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 470-550 of human TOP1MT (NP_443195.1).
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855920
Product Specific Information
Immunogen sequence: RATPSTFEKS MQNLQTKIQA KKEQVAEARA ELRRARAEHK AQGDGKSRSV LEKKRRLLEK LQEQLAQLSV QATDKEENKQ V
Target Information
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA topoisomerase 1, mitochondrial; DNA topoisomerase I, mitochondrial; mitochondrial topoisomerase I; mitochondrial topoisomerase IB; TOP1M; TOP1mt; Topoisomerase I mitochondrial; Type IB Topoisomerase
Gene Aliases: TOP1MT
UniProt ID: (Human) Q969P6, (Rat) Q6IM78
Entrez Gene ID: (Human) 116447, (Rat) 300029
Performance Guarantee
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