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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (IHC) |
1:50-1:200 | - |
Immunocytochemistry (ICC/IF) |
0.25-2 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein corresponding to Human TOP1MT |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2648818 |
Immunogen sequence: GYCILDGHQE KIGNFKIEPP GLFRGRGDHP KMGMLKRRIT PEDVVINCSR DSKIPEPPAG HQWKEVRSDN TVTWLAAWTE SVQNSIKYIM LNPCSKLKGE TAWQKFETAR RLRGFVDEIR SQYRADWKSR EMKTRQ
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA topoisomerase I, mitochondrial; mitochondrial topoisomerase IB; TOP1M; TOP1mt; Topoisomerase I mitochondrial; Type IB Topoisomerase
Gene Aliases: TOP1MT
UniProt ID: (Human) Q86V82
Entrez Gene ID: (Human) 116447
Molecular Function:
DNA topoisomerase
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