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Invitrogen
TOPBP1 Polyclonal Antibody
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Product Details
PA5-65177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human TOPBP1. Recombinant protein control fragment (Product #RP-105925).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KYEAAKKWNLP AVTIAWLLET ARTGKRADES HFLIENSTKE ERSLETEITN GINLNSDTAE HPGTRLQTHR KTVVTPLDMN RFQSKAFRAV VS
Highest antigen sequence identity to the following orthologs - mouse 68%, rat 66%.
Target Information
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; KIAA0259; TOPBP 1; TopBP1; topoisomerase (DNA) II binding protein 1; unnamed protein product
Gene Aliases: Dpb11; KIAA0259; TOP2BP1; TOPBP1
UniProt ID: (Human) Q92547
Entrez Gene ID: (Human) 11073
DNA replication checkpoint
DNA damage checkpoint
double-strand break repair via homologous recombination
DNA metabolic process
DNA replication initiation
DNA repair
double-strand break repair
chromatin organization
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
response to ionizing radiation
mitotic DNA replication checkpoint
reciprocal DNA recombination
chromosome organization
double-strand break repair via classical nonhomologous end joining
double-strand break repair via alternative nonhomologous end joining
broken chromosome clustering
protein localization to site of double-strand break
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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