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This is a rabbit polyclonal antibody raised against residues near the N terminus of human CRTC1.
Immunogen sequence: MATSNNPRK FSEKIALHNQ KQAEETAAFE EVMKDLSLTR AARLQLQKSQ YLQLGPSRGQ YYGGSLPNVN QIGSGTMDLP FQTPFQSSGL DTSRTTRHHG LVDRVYRERG RLGSPHRRPL SVDKHGRQAD SCPYGTMYLS PPADTSWRRT NSDSALHQST MTPTQPESFS SGSQDVHQKR VLLLTVPGME ETTSEADKNL SKQAWDTKKT GSRPKSCEVP GINIFPSADQ ENTTALIPAT HNTGGSLPDL TNIHFPSPLP TPLDPEEPTF PALSSSSSTG NLAANLTHLG IGGAGQGMST P (1-300 aa encoded by BC028050)
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CREB-regulated transcription coactivator 1; CRTC1; FLJ14027; MECT 1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; Mucoepidermoid carcinoma translocated protein 1 homolog; TORC-1; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1
Gene Aliases: AI413414; CRTC1; KIAA0616; MECT1; mKIAA0616; R74955; TORC-1; TORC1; WAMTP1
Molecular Function: transcription cofactor