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Product Details
10441-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TORC1 Fusion Protein Ag0693 (1-300 aa encoded by BC028050)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody raised against residues near the N terminus of human CRTC1.^M
^M
Immunogen sequence: MATSNNPRK FSEKIALHNQ KQAEETAAFE EVMKDLSLTR AARLQLQKSQ YLQLGPSRGQ YYGGSLPNVN QIGSGTMDLP FQTPFQSSGL DTSRTTRHHG LVDRVYRERG RLGSPHRRPL SVDKHGRQAD SCPYGTMYLS PPADTSWRRT NSDSALHQST MTPTQPESFS SGSQDVHQKR VLLLTVPGME ETTSEADKNL SKQAWDTKKT GSRPKSCEVP GINIFPSADQ ENTTALIPAT HNTGGSLPDL TNIHFPSPLP TPLDPEEPTF PALSSSSSTG NLAANLTHLG IGGAGQGMST P (1-300 aa encoded by BC028050)
Target Information
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CREB-regulated transcription coactivator 1; CRTC1; FLJ14027; MECT 1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; Mucoepidermoid carcinoma translocated protein 1 homolog; TORC-1; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1
Gene Aliases: AI413414; CRTC1; KIAA0616; MECT1; mKIAA0616; R74955; TORC-1; TORC1; WAMTP1
UniProt ID: (Human) Q6UUV9, (Mouse) Q6ZQ85
Entrez Gene ID: (Human) 23373, (Mouse) 382056
transcription, DNA-templated
memory
viral process
positive regulation of CREB transcription factor activity
entrainment of circadian clock by photoperiod
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
protein homotetramerization
membrane hyperpolarization
positive regulation of dendrite development
positive regulation of long-term synaptic potentiation
regulation of transcription, DNA-templated
Performance Guarantee
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