TOX3 contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer.
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Protein Aliases: CAG trinucleotide repeat-containing gene F9 protein; TOX high mobility group box family member 3; trinucleotide repeat containing 9; Trinucleotide repeat-containing gene 9 protein
Gene Aliases: 500-9; BC052044; C230068E13; CAGF9; TNRC9; TOX3