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Proteintech
TPCN1 Polyclonal Antibody
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Product Details
23758-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TPCN1 Fusion Protein Ag20607 (1-112 aa encoded by BC136795)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Amount
69 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAVSLDDDV PLILTLDEGG SAPLAPSNGL GQEELPSKNG GSYAIHDSQA PSLSSGGESS PSSPAHNWEM NYQEAAIYLQ EGENNDKFFT HPKDAKALAA YLFAHNHLFY LME (1-112 aa encoded by BC136795)
Target Information
TPCN1 may function as one of the major voltage-gated Ca2+ channel (VDCC) across the plasma membrane. Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ20612; Two pore calcium channel protein 1; Two pore channel protein 1; two-pore channel 1, homolog; unnamed protein product; Voltage-dependent calcium channel protein TPC1
Gene Aliases: 5730403B01Rik; KIAA1169; mKIAA1169; TPC1; TPCN1
UniProt ID: (Human) Q9ULQ1, (Mouse) Q9EQJ0
Entrez Gene ID: (Human) 53373, (Mouse) 252972
ion channel activity
voltage-gated sodium channel activity
calcium channel activity
protein binding
ligand-gated sodium channel activity
syntaxin binding
voltage-gated channel activity
identical protein binding
protein homodimerization activity
NAADP-sensitive calcium-release channel activity
phosphatidylinositol-3,5-bisphosphate binding
intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity
voltage-gated ion channel activity
voltage-gated calcium channel activity
ion channel
transporter
ion transport
calcium ion transport
positive regulation of autophagy
calcium-mediated signaling
ion transmembrane transport
sodium ion transmembrane transport
transmembrane transport
calcium ion transmembrane transport
endocytosis involved in viral entry into host cell
transport
regulation of ion transmembrane transport
membrane depolarization during action potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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