|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (TEPLPEKTQES) corresponding to the C-terminus amino acids of TPD52|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with canine based on sequence homology.
Principal Names: Tumor Protein D52; D52; hD52; N8L; N8 Protein; PC-1; PrLZ; Official Gene Symbol: TPD52 Gene ID: 7163 (Human) Gene Map Locus: 8q21 (Human) TPD52, a 28KDa protein, is a member of D52 protein family. Members of this family have been found to be involved in cell proliferation. TPD52 has a ubiquitous expression pattern and consists of a coiled-coil motif responsible for protein-protein interactions. Its expression is characteristically up-regulated during differentiation of B-cells to plasma cells. It binds to annexin VI in a Ca2+-dependent manner. Reports suggest TPD52 might be involved in Ca2+-dependent signaling, cell proliferation, vesicle trafficking and regulation of secretory processes in plasma cells. It is dysregulated in many cancer types suggesting a therapeutic intervention.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.