This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate and dihydroxy-acetone phosphate in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.
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Protein Aliases: epididymis secretory protein Li 49; Methylglyoxal synthase; MGC88108; TIM; Triose-phosphate isomerase; Triosephosphate isomerase
Gene Aliases: AI255506; HEL-S-49; TIM; TPI; Tpi-1; TPI1; TPID
Molecular Function: isomerase