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Bioss
TPM1/2/3/4 Polyclonal Antibody
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TPM1/2/3/4 Antibody (BS-9622R) in IHC (P)
Paraformaldehyde-fixed, paraffin-embedded Human Myocardial tissue; Antigen retrieval by boiling in sodium citrate buffer (0.01M, pH6) for 15 minutes; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20 minutes; Antibody incubation with Pan-Tropomyosin Polyclonal Antibody, Unconjugated (bs-9622R) at 1:400 overnight at 4°C, followed by incubat... View More
Product Details
BS-9622R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TPM1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha tropomyosin; Alpha-tropomyosin; alpha-tropomyosin, slow skeletal; Beta-tropomyosin; cardiomyopathy, hypertrophic 3; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory protein Li 108; epididymis secretory protein Li 265; epididymis secretory protein Li 273; epididymis secretory sperm binding protein Li 82p; Gamma-tropomyosin; heat-stable cytoskeletal protein 30 kDa; hepatoma alpha tropomyosin; hTM5; nemaline myopathy type 4; nonmuscle tropomyosin 5; sarcomeric tropomyosin kappa; skalphaTM.2; smooth muscle alpha-tropomyosin; striated muscle alpha-tropomyosin; TM-4; TM30p1; tropomycin 4; tropomyosin 3 alpha; tropomyosin 3, gamma; tropomyosin 5; Tropomyosin alpha-1 chain; Tropomyosin alpha-3 chain; Tropomyosin alpha-4 chain; Tropomyosin beta chain; tropomyosin gamma; tropomyosin non-muscle; Tropomyosin-1; Tropomyosin-2; Tropomyosin-3; Tropomyosin-4; Tropomyosin-5
Gene Aliases: 2610528G24Rik; AA986836; AI854628; Alpha-tm; AMCD1; C15orf13; CAPM1; CFTD; CMD1Y; CMH3; DA1; DA2B; gamma-TM; HEL-189; HEL-S-108; HEL-S-265; HEL-S-273; HEL-S-82p; hscp30; HTM-alpha; hTM30nm; hTMnm; LVNC9; NEM1; NEM4; OK/SW-cl.5; TM-5; TM2; TM3; TM30; TM30nm; TM5; Tm5NM; Tma2; TMnm; Tmpa; TMSA; TMSB; Tpm-1; Tpm-2; Tpm-5; TPM1; TPM2; TPM3; TPM4; Tpm4.2; Tpm4.2cy; Tpm5; Tpma; TPMsk3; TRK; Trop-2; Trop-5
UniProt ID: (Human) P09493, (Human) P07951, (Human) P06753, (Human) P67936, (Rat) P04692, (Mouse) P58771, (Rat) P58775, (Mouse) P58774, (Rat) Q63610, (Mouse) P21107, (Rat) P09495, (Mouse) Q6IRU2
Entrez Gene ID: (Human) 7168, (Human) 7169, (Human) 7170, (Human) 7171, (Rat) 24851, (Mouse) 22003, (Rat) 500450, (Mouse) 22004, (Rat) 117557, (Mouse) 59069, (Rat) 24852, (Mouse) 326618
in utero embryonic development
positive regulation of heart rate by epinephrine
movement of cell or subcellular component
muscle contraction
regulation of muscle contraction
cytoskeleton organization
regulation of heart contraction
regulation of cell shape
muscle filament sliding
negative regulation of cell migration
ruffle organization
positive regulation of ATPase activity
cellular response to reactive oxygen species
wound healing
sarcomere organization
positive regulation of cell adhesion
positive regulation of stress fiber assembly
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
regulation of ATPase activity
osteoblast differentiation
actin filament capping
embryo development
brain development
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