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Product Details
11038-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TPM2 Fusion Protein Ag1508 (1-284 aa encoded by BC011776)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDAIKKKMQ MLKLDKENAI DRAEQAEADK KQAEDRCKQL EEEQQALQKK LKGTEDEVEK YSESVKEAQE KLEQAEKKAT DAEADVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA ADESERGMKV IENRAMKDEE KMELQEMQLK EAKHIAEDSD RKYEEVARKL VILEGELERS EERAEVAESR ARQLEEELRT MDQALKSLMA SEEEYSTKED KYEEEIKLLE EKLKEAETRA EFAERSVAKL EKTIDDLEET LASAKEENVE IHQTLDQTLL ELNNL (1-284 aa encoded by BC011776)
Target Information
TPM2 (tropomyosin 2) is beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers. TPM2 binds to actin filaments in muscle and non-muscle cells. Plays a central role in association with the troponin complex in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. Mutations in this gene can cause nemaline myopathy 4, arthrogryposis dital 1A/2B, and cap myopathy 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beta-tropomyosin; epididymis secretory protein Li 273; nemaline myopathy type 4; RP11-112J3.4; tropomyosin; Tropomyosin beta chain; Tropomyosin-2
Gene Aliases: AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB; Tpm-2; TPM2; Trop-2
UniProt ID: (Human) P07951, (Rat) P58775, (Mouse) P58774
Entrez Gene ID: (Human) 7169, (Rat) 500450, (Mouse) 22004
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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