Bethyl Laboratories

TPR Polyclonal Antibody

View all (16) TPR antibodies

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TPR Antibody in Western Blot (WB) — Detection of human TPR by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-TPR antibody BL2149 (Cat. No. A300-826A) used for WB at 0.04 µg/ml (A) and 1 µg/ml (B) and used for IP at 3 µg/mg lysate (B). TPR was also immunoprecipitated by rabbit anti-TPR antibodies BL2148 (Cat. No. A300-825A), BL2150 (Cat. No. A300-827A) and BL2151 (Cat. No. A300-828A), which recognize other epitopes. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 1 second (B).

Product Details

A300-826A

Applications	Tested Dilution	Publications
Western Blot (WB)	1:2,000-1:10,000	-
Immunoprecipitation (IP)	2-5 µg/mg lysate	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Between 1650 and 1700 View antigen
Conjugate	Unconjugated
Form	liquid
Concentration	0.20 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	TBS with 0.1% BSA
Contains	0.09% sodium azide
Storage conditions	4° C

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Target Information

Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; translocated promoter region (to activated MET oncogene); Translocated promoter region protein; tumor potentiating region

Gene Aliases: TPR

UniProt ID: (Human) P12270

Entrez Gene ID: (Human) 7175

Molecular Function: primary active transporter

negative regulation of transcription from RNA polymerase II promoter MAPK import into nucleus RNA import into nucleus RNA export from nucleus mRNA export from nucleus tRNA export from nucleus protein import into nucleus protein export from nucleus nuclear pore organization mitotic nuclear division mitotic nuclear envelope disassembly mitotic spindle assembly checkpoint biological_process regulation of mRNA export from nucleus regulation of glucose transport regulation of mitotic sister chromatid separation viral process protein sumoylation viral transcription gene silencing by RNA positive regulation of heterochromatin assembly regulation of protein stability mRNA export from nucleus in response to heat stress cellular response to heat cellular response to interferon-alpha regulation of protein import into nucleus positive regulation of protein import into nucleus nuclear matrix organization negative regulation of translational initiation regulation of protein export from nucleus positive regulation of protein export from nucleus negative regulation of RNA export from nucleus nuclear pore complex assembly cell division response to epidermal growth factor intracellular transport of virus positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of intracellular protein transport regulation of cellular response to heat regulation of mitotic spindle assembly

Process(es)

molecular_function chromatin binding mRNA binding transporter activity nucleocytoplasmic transporter activity protein binding tubulin binding heat shock protein binding protein homodimerization activity protein anchor poly(A) RNA binding mitogen-activated protein kinase binding dynein complex binding