Peptide sequence: SSEAGLEIDS QQEEEPVQAS DESDLPSTSQ DPPSSSSVDT SSSQPKPFRR
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.
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Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear basket protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; Translocated promoter region; translocated promoter region (to activated MET oncogene); Translocated promoter region and nuclear basket protein; Translocated promoter region protein; tumor potentiating region
Gene Aliases: 2610029M07Rik; BOS_16180; C77892; TPR