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Invitrogen
TPR Polyclonal Antibody
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Product Details
PA5-55054
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TPR. Recombinant protein control fragment (Product #RP-91829).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RRPPHPLPPR LTIHAPPQEL GPPVQRIQMT RRQSVGRGLQ LTPGIGGMQQ HFFDDEDRTV PSTPTLVVPH RTDGFAEAIH SPQVAGVPRF RFGPPEDMPQ TSSSHS
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; translocated promoter region (to activated MET oncogene); Translocated promoter region protein; tumor potentiating region
Gene Aliases: TPR
UniProt ID: (Human) Q99968
Entrez Gene ID: (Human) 7175
molecular_function
chromatin binding
mRNA binding
transporter activity
nucleocytoplasmic transporter activity
protein binding
tubulin binding
heat shock protein binding
protein homodimerization activity
protein anchor
poly(A) RNA binding
mitogen-activated protein kinase binding
dynein complex binding
primary active transporter
negative regulation of transcription from RNA polymerase II promoter
MAPK import into nucleus
RNA import into nucleus
RNA export from nucleus
mRNA export from nucleus
tRNA export from nucleus
protein import into nucleus
protein export from nucleus
nuclear pore organization
mitotic nuclear division
mitotic nuclear envelope disassembly
mitotic spindle assembly checkpoint
biological_process
regulation of mRNA export from nucleus
regulation of glucose transport
regulation of mitotic sister chromatid separation
viral process
protein sumoylation
viral transcription
gene silencing by RNA
positive regulation of heterochromatin assembly
regulation of protein stability
mRNA export from nucleus in response to heat stress
cellular response to heat
cellular response to interferon-alpha
regulation of protein import into nucleus
positive regulation of protein import into nucleus
nuclear matrix organization
negative regulation of translational initiation
regulation of protein export from nucleus
positive regulation of protein export from nucleus
negative regulation of RNA export from nucleus
nuclear pore complex assembly
cell division
response to epidermal growth factor
intracellular transport of virus
positive regulation of mitotic cell cycle spindle assembly checkpoint
positive regulation of intracellular protein transport
regulation of cellular response to heat
regulation of mitotic spindle assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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