Immunogen sequence: RRPPHPLPPR LTIHAPPQEL GPPVQRIQMT RRQSVGRGLQ LTPGIGGMQQ HFFDDEDRTV PSTPTLVVPH RTDGFAEAIH SPQVAGVPRF RFGPPEDMPQ TSSSHS
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.
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Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear basket protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; translocated promoter region; translocated promoter region (to activated MET oncogene); Translocated promoter region protein; tumor potentiating region
Gene Aliases: TPR
UniProt ID: (Human) P12270
Entrez Gene ID: (Human) 7175