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Invitrogen

TPR Polyclonal Antibody

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TPR Polyclonal Antibody

Product Details

PA5-95533

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence of human TPR (MLQAEKKLLEEDVKRWKARNQHLVSQQKD).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807335

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human K562 whole cell, human HL-60 whole cell, human Hela whole cell. IHC: human lung cancer tissue, mouse brain tissue, mouse kidney tissue, rat spleen tissue. Flow: U937 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: megator; NPC-associated intranuclear protein; nuclear pore complex-associated protein TPR; Tpr; TPR; nuclear pore complex-associated protein; translocated promoter region (to activated MET oncogene); translocated promoter region and nuclear basket protein; translocated promoter region protein; tumor potentiating region; unnamed protein product

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Gene Aliases: 2610029M07Rik; MRT79

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UniProt ID: (Human) P12270, (Mouse) F6ZDS4

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Entrez Gene ID: (Human) 7175, (Mouse) 108989, (Rat) 304862

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Function(s)
chromatin binding RNA binding mRNA binding protein binding tubulin binding structural constituent of nuclear pore heat shock protein binding protein homodimerization activity protein anchor mitogen-activated protein kinase binding dynein complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter RNA import into nucleus RNA export from nucleus mRNA export from nucleus protein import into nucleus protein export from nucleus intracellular protein transport nucleocytoplasmic transport nuclear pore organization mitotic spindle assembly checkpoint regulation of mRNA export from nucleus regulation of mitotic sister chromatid separation positive regulation of heterochromatin assembly regulation of protein stability mRNA export from nucleus in response to heat stress regulation of protein localization cellular response to heat cellular response to interferon-alpha regulation of protein import into nucleus positive regulation of protein import into nucleus nuclear matrix organization negative regulation of translational initiation positive regulation of nucleocytoplasmic transport regulation of protein export from nucleus positive regulation of protein export from nucleus negative regulation of RNA export from nucleus nuclear export nuclear pore complex assembly response to epidermal growth factor positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of intracellular protein transport regulation of mitotic spindle assembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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