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Invitrogen
TPR Polyclonal Antibody
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FIGURE: 1 / 9
TPR Antibody (PA5-95533) in IHC (P)
Immunohistochemistry analysis of TPR in paraffin-embedded human lung cancer tissues. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with TPR polyclonal antibody (Product # PA5-95533) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Complex and D... View More
Product Details
PA5-95533
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human TPR (MLQAEKKLLEEDVKRWKARNQHLVSQQKD).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human K562 whole cell, human HL-60 whole cell, human Hela whole cell. IHC: human lung cancer tissue, mouse brain tissue, mouse kidney tissue, rat spleen tissue. Flow: U937 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; Tpr; translocated promoter region (to activated MET oncogene); Translocated promoter region and nuclear basket protein; Translocated promoter region protein; tumor potentiating region; unnamed protein product
Gene Aliases: 2610029M07Rik; C77892; MRT79; TPR
UniProt ID: (Human) P12270, (Mouse) F6ZDS4
Entrez Gene ID: (Human) 7175, (Mouse) 108989, (Rat) 304862
chromatin binding
RNA binding
mRNA binding
protein binding
tubulin binding
structural constituent of nuclear pore
heat shock protein binding
protein homodimerization activity
protein anchor
mitogen-activated protein kinase binding
dynein complex binding
nucleocytoplasmic transporter activity
poly(A) RNA binding
transporter activity
primary active transporter
negative regulation of transcription from RNA polymerase II promoter
RNA import into nucleus
RNA export from nucleus
mRNA export from nucleus
protein import into nucleus
protein export from nucleus
intracellular protein transport
nucleocytoplasmic transport
nuclear pore organization
mitotic spindle assembly checkpoint
regulation of mRNA export from nucleus
regulation of mitotic sister chromatid separation
protein transport
positive regulation of heterochromatin assembly
regulation of protein stability
mRNA export from nucleus in response to heat stress
regulation of protein localization
cellular response to heat
cellular response to interferon-alpha
regulation of protein import into nucleus
positive regulation of protein import into nucleus
nuclear matrix organization
negative regulation of translational initiation
positive regulation of nucleocytoplasmic transport
regulation of protein export from nucleus
positive regulation of protein export from nucleus
negative regulation of RNA export from nucleus
mRNA transport
nuclear export
nuclear pore complex assembly
cell division
response to epidermal growth factor
positive regulation of mitotic cell cycle spindle assembly checkpoint
positive regulation of intracellular protein transport
regulation of mitotic spindle assembly
MAPK import into nucleus
transport
cell cycle
mitotic nuclear division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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