The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
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Protein Aliases: 21 kDa polypeptide; 21 kDa polypeptide under translational control; Fortilin; Histamine-releasing factor; HRF; Lens epithelial protein; p21; p23; TCTP; translationally regulated transcript (21 kDa); Translationally-controlled tumor protein
Gene Aliases: TPT1; Trt