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Bethyl Laboratories
TR2 Polyclonal Antibody
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FIGURE: 1 / 1
TR2 Antibody (A303-047A) in WB
Detection of human and mouse TR2 by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (H; 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (5, 15, and 50 µg for WB) and mouse NIH 3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-TR2 antibody (Product # A303-047A) used for WB at 0.4 µg/mL (A and B) and used for IP at 6 µg/mg lysate. TR2 was also immunoprecipitated by rabbit anti-TR2 antibody A303-046A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times... View More
Product Details
A303-047A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 553 and 603 of Human Testicular Receptor 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Bovine
Target Information
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 80-3 cNDA; early embryonic nuclear receptor; mTR2; nr2c1; NR2C1v1; NR2C1v2; Nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group H, member 1; Orphan nuclear receptor TR2; orphan receptor, TR2-11; steroid receptor TR2; steroid receptor TR2-11; steroid receptor TR2-9; Testicular receptor 2; TR2 nuclear hormone receptor; unnamed protein product
Gene Aliases: 4831444H07Rik; 80.3; Eenr; NR2C1; TR2; Tr2-11
UniProt ID: (Human) P13056, (Mouse) Q505F1
Entrez Gene ID: (Human) 7181, (Mouse) 22025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
signaling receptor activity
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell differentiation
intracellular steroid hormone receptor signaling pathway
intracellular receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of retinoic acid receptor signaling pathway
transcription, DNA-templated
transcription from RNA polymerase II promoter
steroid hormone mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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