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|Tested species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (119 CQKYIDKYGPLQELEE 134) of TRAC-1 protein.|
|Storage buffer||whole serum with 50% glycerol|
|Contains||0.025% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
TRAC-1 is a 232 amino acid protein containing an N-terminal RING-type zinc finger domain. It functions as a positive regulator in the T-cell receptor signaling pathway, thus leading to T-cell activation. It mediates ubiquitination and subsequent proteasomal degradation of target proteins. TRAC-1 is expressed in lymphoid tissues, including bone marrow, spleen, thymus as well as in other tissues. It is predominantly expressed in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ring finger protein 125, E3 ubiquitin protein ligase; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TRAC-1; TRAC1
RNF125; TNORS; TRAC-1; TRAC1