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Proteintech
TRADD Polyclonal Antibody
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Product Details
15468-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRADD Fusion Protein Ag7768 (1-312 aa encoded by BC004491)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAGQNGHE EWVGSAYLFV ESSLDKVVLS DAYAHPQQKV AVYRALQAAL AESGGSPDVL QMLKIHRSDP QLIVQLRFCG RQPCGRFLRA YREGALRAAL QRSLAAALAQ HSVPLQLELR AGAERLDALL ADEERCLSCI LAQQPDRLRD EELAELEDAL RNLKCGSGAR GGDGEVASAP LQPPVPSLSE VKPPPPPPPA QTFLFQGQPV VNRPLSLKDQ QTFARSVGLK WRKVGRSLQR GCRALRDPAL DSLAYEYERE GLYEQAFQLL RRFVQAEGRR ATLQRLVEAL EENELTSLAE DLLGLTDPNG GLA (1-312 aa encoded by BC004491)
Target Information
TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; tradd; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein; unnamed protein product
Gene Aliases: 9130005N23Rik; AA930854; Hs.89862; TRADD
UniProt ID: (Human) Q15628, (Mouse) Q3U0V2
Entrez Gene ID: (Human) 8717, (Mouse) 71609
transmembrane receptor protein tyrosine kinase adaptor activity
protein binding
kinase binding
protein binding, bridging
signaling adaptor activity
identical protein binding
binding, bridging
death domain binding
signal transducer activity
tumor necrosis factor receptor binding
protein complex binding
apoptotic process
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
I-kappaB kinase/NF-kappaB signaling
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of cell migration
tumor necrosis factor-mediated signaling pathway
TRAIL-activated apoptotic signaling pathway
NIK/NF-kappaB signaling
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of inflammatory response
positive regulation of hair follicle development
cellular response to tumor necrosis factor
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
regulation of apoptotic process
protein heterooligomerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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