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Proteintech
TRAF2 Polyclonal Antibody
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Product Details
26846-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRAF2 Fusion Protein Ag25387 (438-501 aa encoded by BC032410)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NNREHVIDA FRPDVTSSSF QRPVNDMNIA SGCPLFCPVS KMEAKNSYVR DDAIFIKAIV DLTGL (438-501 aa encoded by BC032410)
Target Information
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adapter protein; E3 ubiquitin-protein ligase TRAF2; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3; unnamed protein product
Gene Aliases: MGC:45012; RNF117; TRAF2; TRAP; TRAP3
UniProt ID: (Human) Q12933
Entrez Gene ID: (Human) 7186
ubiquitin-protein transferase activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
lipid binding
transferase activity
enzyme binding
protein kinase binding
protein phosphatase binding
protein binding, bridging
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
tumor necrosis factor receptor superfamily binding
signaling adaptor activity
identical protein binding
tumor necrosis factor binding
macromolecular complex binding
sphingolipid binding
metal ion binding
ubiquitin protein ligase activity
regulation of immunoglobulin production
regulation of production of molecular mediator of immune response
positive regulation of T cell cytokine production
apoptotic process
signal transduction
positive regulation of gene expression
programmed cell death
protein ubiquitination
signal transduction involved in regulation of gene expression
CD40 signaling pathway
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
NIK/NF-kappaB signaling
TORC1 signaling
TORC2 signaling
T cell activation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
regulation of MAPK cascade
positive regulation of JUN kinase activity
innate immune response
regulation of JNK cascade
mRNA stabilization
positive regulation of NF-kappaB transcription factor activity
protein autoubiquitination
protein-containing complex assembly
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein K63-linked ubiquitination
cellular response to nitric oxide
programmed necrotic cell death
interleukin-17-mediated signaling pathway
CD27 signaling pathway
positive regulation of tumor necrosis factor-mediated signaling pathway
TORC1 complex assembly
TORC2 complex disassembly
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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