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Product Details
PA5-50277
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein corresponding to residues near the C terminal of human TNF receptor-associated factor 3 interacting protein 1
Conjugate
Form
Liquid
Concentration
1.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2635730
Product Specific Information
The antibody detects endogenous levels of total TRAF3IP1 protein.
Target Information
Tumor necrosis factor receptor (TNFR) superfamily members transmit signals regulating proliferation, differentiation and apoptosis in various types of cells. TNFR-associated factors (TRAFs) are a family of proteins that were initially discovered as downstream signal transducers of the TNFR superfamily. TRAF3 contains an N-terminal ring finger/zinc finger region that is thought to be essential for downstream signaling. MIP-T3 is associated with TRAF3. MIP-T3 binds to taxol-stabilized microtubules and to tubulin in vitro, and MIP-T3 recruits TRAF3 to microtubules when both proteins are overexpressed. The MIP-T3/TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3. This interaction may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: interleukin 13 receptor alpha 1-binding protein-1; Interleukin-13 receptor alpha 1-binding protein 1; Intraflagellar transport protein 54 homolog; microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; microtubule-interacting protein that associates with TRAF3; MIP-T3; TNF receptor-associated factor 3 interacting protein 1; TRAF3-interacting protein 1
Gene Aliases: 3930402D05Rik; AU041749; IFT54; MIP-T3; MIPT3; SLSN9; TRAF3IP1
UniProt ID: (Human) Q8TDR0, (Mouse) Q149C2
Entrez Gene ID: (Human) 26146, (Mouse) 74019
morphogenesis of a polarized epithelium
kidney development
negative regulation of protein phosphorylation
neural tube patterning
embryonic camera-type eye development
negative regulation of protein complex assembly
negative regulation of type I interferon production
negative regulation of interferon-beta production
embryonic heart tube development
post-anal tail morphogenesis
intraciliary transport
cilium assembly
embryonic digit morphogenesis
negative regulation of defense response to virus
regulation of microtubule cytoskeleton organization
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
negative regulation of transcription from RNA polymerase II promoter
negative regulation of tyrosine phosphorylation of Stat6 protein
regulation of DNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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