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Bethyl Laboratories
TRAF4 Polyclonal Antibody
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Product Details
A302-841A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 420 and 470 of Human TNF Receptor-Associated Factor 4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkB. Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process. Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cysteine-rich domain associated with ring and TRAF domain; Cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83; RNF83malignant 62; TNF receptor-associated factor 4; TRAF4 variant 6; tumor necrosis receptor-associated factor 4A
Gene Aliases: CART1; MLN62; RNF83; TRAF4
UniProt ID: (Human) Q9BUZ4
Entrez Gene ID: (Human) 9618
apoptotic process
signal transduction
activation of NF-kappaB-inducing kinase activity
respiratory gaseous exchange
protein ubiquitination
respiratory tube development
regulation of apoptotic process
positive regulation of protein kinase activity
positive regulation of JNK cascade
positive regulation of protein homodimerization activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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