This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: GAFDNLLEWP FARRVTFSLL DQSDPGLAKP QHVTETFHPD PNWKNFQKPG TWRGSLDESS LGFGYPKFIS HQDIRKRNYV RDDAVFIRAA VELPRKI
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkB. Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process. Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cysteine-rich domain associated with ring and TRAF domain; Cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83; RNF83malignant 62; TNF receptor-associated factor 4; TRAF4 variant 6; tumor necrosis receptor-associated factor 4A
Gene Aliases: CART1; MLN62; RNF83; TRAF4
UniProt ID: (Human) Q9BUZ4
Entrez Gene ID: (Human) 9618
Molecular Function: signaling molecule