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Proteintech
TRAF5 Polyclonal Antibody
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Product Details
12868-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRAF5 Fusion Protein Ag3519 (209-557 aa encoded by BC029600)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DEHLAVCPE AEQDCPFKHY GCAVTDKRRN LQQHEHSALR EHMRLVLEKN VQLEEQISDL HKSLEQKESK IQQLAETIKK LEKEFKQFAQ LFGKNGSFLP NIQVFASHID KSAWLEAQVH QLLQMVNQQQ NKFDLRPLME AVDTVKQKIT LLENNDQRLA VLEEETNKHD THINIHKAQL SKNEERFKLL EGTCYNGKLI WKVTDYKMKK REAVDGHTVS IFSQSFYTSR CGYRLCARAY LNGDGSGRGS HLSLYFVVMR GEFDSLLQWP FRQRVTLMLL DQSGKKNIME TFKPDPNSSS FKRPDGEMNI ASGCPRFVAH SVLENAKNAY IKDDTLFLKV AVDLTDLEDL (209-557 aa encoded by BC029600)
Target Information
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation (5).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: RING finger protein 84; TNF receptor-associated factor 5; TRAF5; unnamed protein product
Gene Aliases: MGC:39780; RNF84; TRAF5
UniProt ID: (Human) O00463, (Mouse) P70191
Entrez Gene ID: (Human) 7188, (Mouse) 22033
tumor necrosis factor receptor binding
protein binding
zinc ion binding
ubiquitin protein ligase binding
thioesterase binding
signaling adaptor activity
identical protein binding
metal ion binding
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
signal transducer activity
scaffold/adaptor protein
apoptotic process
signal transduction
cell surface receptor signaling pathway
positive regulation of cell proliferation
signal transduction involved in regulation of gene expression
CD40 signaling pathway
tumor necrosis factor-mediated signaling pathway
regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
mRNA stabilization
positive regulation of NF-kappaB transcription factor activity
interleukin-17-mediated signaling pathway
protein ubiquitination
positive regulation of sequence-specific DNA binding transcription factor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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