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Fabgennix

TRAF6 Polyclonal Antibody

View all (27) TRAF6 antibodies

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Product Details

TRAF6-601AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on TRAF6 protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6; TNF receptor-associated factor 6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; unnamed protein product

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Gene Aliases: MGC:3310; RNF85; TRAF6

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UniProt ID: (Human) Q9Y4K3

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Entrez Gene ID: (Human) 7189

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Function(s)
ubiquitin-protein transferase activity tumor necrosis factor receptor binding protein binding zinc ion binding transferase activity enzyme binding protein binding, bridging ubiquitin conjugating enzyme binding ubiquitin-ubiquitin ligase activity signaling adaptor activity identical protein binding histone deacetylase binding protein kinase B binding metal ion binding ubiquitin protein ligase activity
Process(es)
autophagosome assembly negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination ossification in utero embryonic development neural tube closure stimulatory C-type lectin receptor signaling pathway immune system process regulation of immunoglobulin production positive regulation of T cell cytokine production cytoplasmic pattern recognition receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway immune response cellular response to DNA damage stimulus signal transduction I-kappaB kinase/NF-kappaB signaling mRNA transcription organ morphogenesis protein ubiquitination antigen processing and presentation of exogenous peptide antigen via MHC class II CD40 signaling pathway osteoclast differentiation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway positive regulation of lipopolysaccharide-mediated signaling pathway activation of protein kinase activity positive regulation of type I interferon production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-6 production tumor necrosis factor-mediated signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway interleukin-33-mediated signaling pathway interleukin-17A-mediated signaling pathway T-helper 1 type immune response positive regulation of T cell proliferation odontogenesis of dentin-containing tooth defense response to bacterium regulation of apoptotic process myeloid dendritic cell differentiation regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity innate immune response bone resorption positive regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade bone remodeling cell development T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity protein autoubiquitination interleukin-1-mediated signaling pathway protein K63-linked ubiquitination response to interleukin-1 protein K48-linked ubiquitination cellular response to lipopolysaccharide cellular response to cytokine stimulus interleukin-17-mediated signaling pathway regulation of neurotransmitter receptor localization to postsynaptic specialization membrane antiviral innate immune response intracellular signaling cassette protein branched polyubiquitination cellular response to oxygen-containing compound positive regulation of leukocyte adhesion to vascular endothelial cell
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