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Invitrogen
TRAIL-R2 (DR5) Polyclonal Antibody
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FIGURE: 1 / 4
TRAIL-R2 (DR5) Antibody (PA5-23095) in ICC/IF
Immunocytochemistry analysis of TRAIL-R2 (DR5) in HepG2 cells. Samples were incubated with TRAIL-R2 (DR5) polyclonal antibody (Product # PA5-23095) using a dilution of 5 µg/mL overnight at 4°C followed by anti-rabbit Dylight 488 (Green) at a dilution of 1:500. Cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. Alpha tubulin (DM1A) was use... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-23095
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acids 388 to 407 (isoform 2) of human DR5 precursor (1,2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA5-23095 targets DR5/TRAILR2 in FACS, ICC, IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-23095 immunogen is synthetic peptide (388 CKWVNKTGRDASVHTLLDALE 407) of DR5/TRAILR2 protein.
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD262; Death receptor 5; dr-5; KILLER/DR5 TRAIL death-inducing receptor; MK; sCD262; soluble CD262; Tumor necrosis factor receptor superfamily member 10B
Gene Aliases: DR5; KILLER; Ly98; MK; Tnfrsf10b; TRAILR2; TRICK2A; TRICK2B; TRICKB
UniProt ID: (Mouse) Q9QZM4
Entrez Gene ID: (Mouse) 21933
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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