Immunogen sequence: CTPRRLSLAES FTNTRESTTT MSTSLGLVWL LKERGISAAV YDPQSWDRAG RGSLLHSYTP KMAVIPSTPP NSPMQTPTSS PPSFEFKCTS PPYDNFLASK PASSILREVR EKNVRSSESQ TDVSVSNLNL VD
Highest antigen sequence identity to the following orthologs - mouse 95%, rat 95%.
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 106 kDa O-GlcNAc transferase-interacting protein; milton homolog 1; O-linked N-acetylglucosamine transferase interacting protein 106; OGT(O-Glc-NAc transferase)-interacting protein 106 KDa; Protein Milton; Trafficking kinesin-binding protein 1; trafficking protein, kinesin binding 1
Gene Aliases: KIAA1042; MILT1; OIP106; TRAK1
UniProt ID: (Human) Q9UPV9
Entrez Gene ID: (Human) 22906
Molecular Function: membrane traffic protein