NIBP is a 1246 amino acid intracellular regulatory protein. Reports suggest that NIBP physically interacts with NIK, IKK (beta), but not IKK (alpha) or IKK (gamma) and thus acts as a novel enhancer of cytokine-induced NF-(kappa) B signaling pathway. Due to its neuronal expression NIBP is considered as a potential target for modulating the NF-(kappa) B signaling cascade in neuronal pathologies dependent upon abnormal activation of this pathway. NIBP is mainly expressed in brain, muscle, heart, and kidney.
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Protein Aliases: IKK2 binding protein; NIK and IKK(beta) binding protein; NIK and IKK-beta binding protein; NIK- and IKBKB-binding protein; Trafficking protein particle complex subunit 9; TRAPP 120 kDa subunit; Tularik gene 1 protein
Gene Aliases: 1810044A24Rik; 2900005P22Rik; 4632408O18Rik; IBP; IKBKBBP; KIAA1882; mKIAA1882; MRT13; NIBP; T1; TRAPPC9; TRS120; TRS130