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TRESK Polyclonal Antibody
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FIGURE: 1 / 3
TRESK Antibody (600-401-FN4) in ICC/IF
Immunofluorescence Microscopy of TRESK antibody. Tissue: Rat brain cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: TRESK antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: TRESK is nuclear and cytoplasmic. Staining: TRESK as red fluorescent signal.
Product Details
600-401-FN4
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-TRESK antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the internal region of human TRESK.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2P K ion channel TRESK; Potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; potassium channel, two pore domain subfamily K, member 18; tandem-pore K+ (K(2P)) channel; Tresk-2; TWIK-related individual K+ channel; TWIK-related individual potassium channel; TWIK-related spinal cord K+ channel; TWIK-related spinal cord potassium channel; Two-pore-domain potassium channel TRESK
Gene Aliases: Gm781; K2p18.1; KCNK18; MGR13; TRESK; TRESK-2; TRESK2; TRIK
UniProt ID: (Human) Q7Z418, (Rat) Q6Q1P3, (Mouse) Q6VV64
Entrez Gene ID: (Human) 338567, (Rat) 445371, (Mouse) 332396
ion transport
potassium ion transport
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
ion transmembrane transport
cellular response to pH
potassium ion transmembrane transport
potassium ion export across plasma membrane
potassium ion export
transport
stabilization of membrane potential
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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